GPCR Programs
Helical Hormone Mimetics
The secretin family of the GPCRs binds helical peptide hormones. These include GLP1, calcitonin and parathyroid hormone. The image to the left is the GLP1 peptide (white helix) bound to the extracellular domain of its receptor.
The potential exists to create stabilised truncated versions of these hormones using our technology. We are interested in discussing licensing opportunities in this area.
Small Molecule Project 1 - CGRP Scaffold Swap
We have identified an opportunity for a molecular scaffold change within the small molecule CGRP antagonists field. This therapeutic class has been validated recently by the approval of several antibody therapeutics, with some small molecule therapeutics currently pending approval (late 2019). This program is an opportunistic value equation - the attraction of our position being newly patentable matter and the avoidance of some chemical functionality that may have led to liver toxicity failures of other CGRP antagonists in late stage trials.
Small Molecule Project 2 - Peptide Receptor Antagonist
Our second opportunistic small molecule project is a scaffold modification to novate and advance an existing series of GPCR antagonists. This is a first in class drug opportunity for a high value market and builds on significant in house experience in the specific field.
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